The vice president of Uganda is the second-highest executive official in the Ugandan government. The vice president is appointed by the president.
| Name | Inaugurated | Left office | President | Notes |
|---|---|---|---|---|
| William Wilberforce Kadhumbula Nadiope III | October 1963 | April 1966 | Edward Mutesa | Deposed during the Mengo Crisis |
| John Babiiha | April 1966 | January 1971 | Milton Obote | Deposed in the 1971 coup d'état |
| Vacant | January 1971 | January 1977 | ||
| Mustafa Adrisi | January 1977 | Disputed; de facto April 1978 | Idi Amin | Adrisi was factually disempowered by President Idi Amin in April 1978, but refused to accept his dismissal as Vice President. He remained in Uganda until mid-1979, maintaining a low profile but still claiming to be Vice President. When Amin was overthrown in the Uganda–Tanzania War, Adrisi fled into exile where he continued to pose as Vice President. |
| Disputed; claimed by Mustafa Adrisi | November 1978 | December 1980 | ||
| Paulo Muwanga | December 1980 | July 1985 | Milton Obote | Deposed in the 1985 coup d'état |
| Vacant | July 1985 | January 22, 1991 | ||
| Samson Kisekka | January 22, 1991 | November 1994 | Yoweri Museveni | |
| Specioza Kazibwe | November 18, 1994 | May 21, 2003 | The first woman in Africa to hold the position of vice-president of a sovereign nation | |
| Gilbert Bukenya | May 23, 2003 | May 23, 2011 | ||
| Edward Ssekandi | May 24, 2011 | June 21, 2021 | ||
| Jessica Alupo | June 21, 2021 | Incumbent | The Second Woman Vice President of Uganda after Specioza Wandera Kazibwe | |