YKT6 explained
Synaptobrevin homolog YKT6 is a protein that in humans is encoded by the YKT6 gene.[1] [2] [3]
Function
This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway.[3]
Interactions
YKT6 has been shown to interact with BET1L.[4] [5]
References
Further reading
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- McNew JA, Sogaard M, Lampen NM, Machida S, Ye RR, Lacomis L, Tempst P, Rothman JE, Söllner TH . Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport . The Journal of Biological Chemistry . 272 . 28 . 17776–83 . Jul 1997 . 9211930 . 10.1074/jbc.272.28.17776 . free .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Tochio H, Tsui MM, Banfield DK, Zhang M . An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p . Science . 293 . 5530 . 698–702 . Jul 2001 . 11474112 . 10.1126/science.1062950 . 13618305 .
- Honer WG, Falkai P, Bayer TA, Xie J, Hu L, Li HY, Arango V, Mann JJ, Dwork AJ, Trimble WS . Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness . Cerebral Cortex . 12 . 4 . 349–56 . Apr 2002 . 11884350 . 10.1093/cercor/12.4.349 . free .
- Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G . Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115 . The Journal of Cell Biology . 157 . 1 . 45–62 . Apr 2002 . 11927603 . 2173270 . 10.1083/jcb.200112127 .
- Xu Y, Martin S, James DE, Hong W . GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus . Molecular Biology of the Cell . 13 . 10 . 3493–507 . Oct 2002 . 12388752 . 129961 . 10.1091/mbc.E02-01-0004 .
- Puri N, Kruhlak MJ, Whiteheart SW, Roche PA . Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly . Journal of Immunology . 171 . 10 . 5345–52 . Nov 2003 . 14607937 . 10.4049/jimmunol.171.10.5345 . free .
- Fukasawa M, Varlamov O, Eng WS, Söllner TH, Rothman JE . Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation . Proceedings of the National Academy of Sciences of the United States of America . 101 . 14 . 4815–20 . Apr 2004 . 15044687 . 387331 . 10.1073/pnas.0401183101 . free .
- Tai G, Lu L, Wang TL, Tang BL, Goud B, Johannes L, Hong W . Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network . Molecular Biology of the Cell . 15 . 9 . 4011–22 . Sep 2004 . 15215310 . 515336 . 10.1091/mbc.E03-12-0876 .
- Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
- Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I . Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system . The Journal of Biological Chemistry . 281 . 7 . 4495–506 . Feb 2006 . 16354670 . 10.1074/jbc.M509715200 . free .
- Ooe A, Kato K, Noguchi S . Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers . Breast Cancer Research and Treatment . 101 . 3 . 305–15 . Mar 2007 . 16821082 . 10.1007/s10549-006-9293-x . 2398124 .
Notes and References
- Veit M . The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues . The Biochemical Journal . 384 . Pt 2 . 233–7 . Dec 2004 . 15479160 . 1134105 . 10.1042/BJ20041474 .
- Rossi V, Banfield DK, Vacca M, Dietrich LE, Ungermann C, D'Esposito M, Galli T, Filippini F . Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators . Trends in Biochemical Sciences . 29 . 12 . 682–8 . Dec 2004 . 15544955 . 10.1016/j.tibs.2004.10.002 . 26297648 .
- Web site: Entrez Gene: YKT6 YKT6 v-SNARE homolog (S. cerevisiae).
- Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G . Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115 . The Journal of Cell Biology . 157 . 1 . 45–62 . Apr 2002 . 11927603 . 2173270 . 10.1083/jcb.200112127 .
- Xu Y, Martin S, James DE, Hong W . GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus . Molecular Biology of the Cell . 13 . 10 . 3493–507 . Oct 2002 . 12388752 . 129961 . 10.1091/mbc.E02-01-0004 .