Aminotransferase, class V explained

Aminotransferase class-V is an evolutionary conserved protein domain. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-. Aminotransferases share certain mechanistic features with other pyridoxal- phosphate dependent enzymes, such as the covalent binding of the pyridoxal- phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped[1] into subfamilies. This family is called class-V.

Human proteins containing this domain

AGXT

KYNU; MOCOS; NFS1; PSAT1; SCLY; TLH6;

Notes and References

  1. Ouzounis C, Sander C . Homology of the NifS family of proteins to a new class of pyridoxal phosphate-dependent enzymes . FEBS Letters . 322 . 2 . 159–64 . May 1993 . 8482384 . 10.1016/0014-5793(93)81559-I . 14587217 . free . 1993FEBSL.322..159O .