Bemotrizinol Explained
Bemotrizinol (INN[1] [2] /USAN,[3] INCI bis-ethylhexyloxyphenol methoxyphenyl triazine) is an oil-soluble organic compound that is added to sunscreens to absorb UV rays. It is marketed as Parsol Shield, Tinosorb S, and Escalol S.
Bemotrizinol is a broad-spectrum UV absorber, absorbing UVB as well as UVA rays. It has two absorption peaks, 310 and 340 nm.[4] It is highly photostable. Even after 50 MEDs (minimal erythemal doses), 98.4% remains intact. It helps prevent the photodegradation of other sunscreen actives like avobenzone.[5] Tinosorb S Aqua, recently developed by BASF, is bemotrizinol in a PMMA matrix dispersed in water. This makes it possible to add bemotrizinol to the water phase.[6]
Bemotrizinol has strong synergistic effects on the SPF when formulated with bisoctrizole, ethylhexyl triazone or iscotrizinol.[7] It is the most effective UV absorber available measured by SPF, based on the maximum concentration permitted by European legislation.[8]
As of 2022,[9] bemotrizinol is not approved by the United States Food and Drug Administration for use in sunscreens, but has been approved in the European Union since 2000[10] and some other parts of the world, including Australia.[11] [12]
Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro.[13]
Notes and References
- Web site: Home . 2008-09-19 . https://web.archive.org/web/20070919195045/http://whqlibdoc.who.int/druginfo/18_4_2004_INN92.pdf . 2007-09-19 . dead .
- Web site: Home . 2008-09-28 . https://web.archive.org/web/20091016221356/http://whqlibdoc.who.int/druginfo/INN_2005_list54.pdf . 2009-10-16 . dead .
- Web site: Archived copy . 2007-08-19 . https://web.archive.org/web/20070929140612/http://www.ama-assn.org/ama1/pub/upload/mm/365/bemotrizinol.doc . 2007-09-29 . dead .
- Sunscreens with an absorption maximum of > or =360 nm provide optimal protection against UVA1-induced expression of matrix metalloproteinase-1, interleukin-1, and interleukin-6 in human dermal fibroblasts. March 2006. 16520862. Vielhaber G, Grether-Beck S, Koch O, Johncock W, Krutmann J. Photochem Photobiol Sci. 5 . 275 - 82. 10.1039/b516702g. 3.
- Photostabilization of Butyl methoxydibenzoylmethane (Avobenzone) and Ethylhexyl methoxycinnamate by Bis-ethylhexyloxyphenol methoxyphenyl triazine (Tinosorb S), a new UV broadband filter. September 2001. 11594052. Chatelain E, Gabard B. Photochem Photobiol. 74 . 401–6. 10.1562/0031-8655(2001)074<0401:POBMAA>2.0.CO;2. 3. 29879472.
- Web site: basf-chemtrade.de. www.basf-chemtrade.de. 2011-04-15. https://web.archive.org/web/20110905022305/http://www.basf-chemtrade.de/images/stories/broschueren/PCI/100413_tinosorb_s_aqua.pdf. 2011-09-05. dead.
- Web site: BASF – Global Home.
- Study of the efficacy of 18 sun filters authorized in European Union tested in vitro. June 2007. 17663193. Couteau C, Pommier M, Paparis E, Coiffard LJ. Pharmazie. 62 . 449–52. 6 . 10.1691/ph.2007.6.6247.
- News: Mull . Amanda . You're Not Allowed to Have the Best Sunscreens in the World . 2 July 2022 . The Atlantic . 1 July 2022 . en.
- 10.1007/s001030170019 . Über den Lichtschutzfaktor hinaus - neue effiziente und photostabile UVA-Filter . Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz . 44 . 5 . 463–470 . 2001 . Osterwalder . U. . Luther . H. . Herzog . B. . 36985446 .
- NEW-WAVE SUNSCREENS: Active ingredient makers are frustrated by the long list of sunscreens and UV-A testing protocols that are still awaiting FDA decisions . . April 11, 2005 . 83 . 15 . 18–22 . 10.1021/cen-v083n015.p018 . subscription .
- Web site: Australian Regulatory Guidelines for OTC Medicines - Chapter 10. https://web.archive.org/web/20070831075404/http://tga.gov.au/docs/pdf/argom_10.pdf. dead. August 31, 2007.
- Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S. December 2001. 11754532. Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA. Regul Toxicol Pharmacol. 34 . 287–91. 10.1006/rtph.2001.1511. 3.